1. Kaiser, D. and Othmer, S. (2000). Effect of Neurofeedback on Variables of Attention in a Large Multi-Center Trial. Journal of Neurotherapy, 4(1), pp.5-15.

ABSTRACT: Neurofeedback training produced significant improvement in attentiveness, impulse control, and response variability. Significant clinical improvement in one or more measures was seen in eighty-five percent of those subjects with moderate pre-training deficits.

2.  Arns, M., de Ridder, S., Strehl, U., Breteler, M. and Coenen, A. (2009). Efficacy of Neurofeedback Treatment in ADHD: The Effects on Inattention, Impulsivity and Hyperactivity: A Meta-Analysis. Clinical EEG and Neuroscience, 40(3), pp.180-189.

ABSTRACT: In line with the AAPB and ISNR guidelines for rating clinical efficacy, we conclude that neurofeedback treatment for ADHD can be considered “Efficacious and Specific” (Level 5) with a large ES for inattention and impulsivity and a medium ES for hyperactivity.

3.  Lubar, J., Swartwood, M., Swartwood, J. and O’Donnell, P. (1995). Evaluation of the effectiveness of EEG neurofeedback training for ADHD in a clinical setting as measured by changes in T.O.V.A. scores, behavioral ratings, and WISC-R performance. Biofeedback and Self-Regulation, 20(1), pp.83-99.

ABSTRACT: This study is significant in that it examines the effects of neurofeedback training on both objective and subjective measures under relatively controlled conditions. Our findings corroborate and extend previous research, indicating that neurofeedback training can be an appropriate and efficacious treatment for children with ADHD.

4.  Barabasz, A. and Barabasz, M. (1995). Attention Deficit Hyperactivity Disorder:. Journal of Neurotherapy, 1(1), pp.1-10.

ABSTRACT: Neurotherapy (or EEG feedback), which addresses the frontal lobe dysfunction, has shown significant, long-term results, by teaching patients to normalize their brainwave responses to stimuli.

5.  Nash, J. (2000). Treatment of Attention Deficit Hyperactivity Disorder with Neurotherapy. Clinical Electroencephalography, 31(1), pp.30-37.

ABSTRACT: Neurotherapy for ADHD offers an effective alternate for patients whose treatment is limited by side effects, poor medication response and in cases in which the patients and/or their parents refuse to consider medications. Studies indicate clinical improvement is largely related to measurable improvements in the EEG signature, evidenced by declining theta/beta ratios over frontal/central cortex and/or reduced theta/alpha band amplitudes.

6. HAMMOND, D. (2005). Neurofeedback with anxiety and affective disorders. Child and Adolescent Psychiatric Clinics of North America, 14(1), pp.105-123.

ABSTRACT: A review of more recent research finds that pharmacologic treatment may not be as effective as previously believed. A more recent neuroscience technology, electroencephalographic (EEG) biofeedback (neurofeedback), seems to hold promise as a methodology for retraining abnormal brain wave patterns.

7. Keller, I. (2001). Neurofeedback Therapy of Attention Deficits in Patients with Traumatic Brain Injury. Journal of Neurotherapy, 5(1-2), pp.19-32.

ABSTRACT: After ten sessions the analyses of beta activity showed that eight patients were able to increase their beta activity while the remaining four patients showed a decrease of beta activity. Mean duration of beta activity was prolonged about 50% after training. Patients who received NFT improved significantly more in the attention tests than control patients.

8. Mennella, R., Patron, E. and Palomba, D. (2017). Frontal alpha asymmetry neurofeedback for the reduction of negative affect and anxiety. Behaviour Research and Therapy, 92, pp.32-40.

ABSTRACT: Frontal alpha asymmetry has been proposed to underlie the balance between approach and withdrawal motivation associated to each individual’s affective style. Neurofeedback of EEG frontal alpha asymmetry represents a promising tool to reduce negative affect. These findings provide a strong rationale for the use of frontal alpha asymmetry neurofeedback for the reduction of negative affect and anxiety in clinical settings

9. McKnight, J. and Fehmi, L. (2001). Attention and Neurofeedback Synchrony Training: Clinical Results and Their Significance. Journal of Neurotherapy, 5(1-2), pp.45-61.

ABSTRACT: Analysis of 132 cases using this dual approach found that more than 90 percent of the patients reported an alleviation of symptoms. These positive results were found with stress-induced headache, joint pain, and gastrointestinal disease.

10. White, E., Groeneveld, K., Tittle, R., Bolhuis, N., Martin, R., Royer, T. and Fotuhi, M. (2017). Erratum to: Combined Neurofeedback and Heart Rate Variability Training for Individuals with Symptoms of Anxiety and Depression: A Retrospective Study. NeuroRegulation, 4(2), pp.99-99.

ABSTRACT: We present evidence that NFB+HRV training may provide an effective, nonpharmaceutical intervention to reduce symptoms of anxiety and depression in children and adults. Additionally, NFB+HRV training may improve EEG, blood pressure, resting breathing rate, and HRV.

11. Baruth, J., Casanova, M., El-Baz, A., Horrell, T., Mathai, G., Sears, L. and Sokhadze, E. (2010). Low-Frequency Repetitive Transcranial Magnetic Stimulation Modulates Evoked-Gamma Frequency Oscillations in Autism Spectrum Disorder. Journal of Neurotherapy, 14(3), pp.179-194.

ABSTRACT: We proposed that ‘slow’ rTMS may have increased cortical inhibitory tone which improved discriminatory gamma activity at early stages of visual processing. rTMS has the potential to become an important therapeutic tool in ASD treatment and has shown significant benefits in treating core symptoms of ASD with few, if any side effects.

12. Coben, R., Mohammad-Rezazadeh, I. and Cannon, R. (2014). Using quantitative and analytic EEG methods in the understanding of connectivity in autism spectrum disorders: a theory of mixed over- and under-connectivity. Frontiers in Human Neuroscience, 8.

ABSTRACT: Neuroimaging technologies and research has shown that autism is largely a disorder of neuronal connectivity. While advanced work is being done with fMRI, MRI-DTI, SPECT and other forms of structural and functional connectivity analyses, the use of EEG for these purposes is of additional great utility.

13. Knezevic, B., Thompson, L. and Thompson, M. (2010). Pilot Project to Ascertain the Utility of Tower of London Test to Assess Outcomes of Neurofeedback in Clients with Asperger’s Syndrome. Journal of Neurotherapy, 14(1), pp.3-19.

ABSTRACT: Following the training, clients with AS were able to plan more efficiently, inhibit premature responses, and shift set with greater ease, as well as solve problems more quickly as measured by their ToLDX scores. On CPTs, clients with AS showed a trend toward less impulsivity.

14. Kouijzer, M., de Moor, J., Gerrits, B., Buitelaar, J. and van Schie, H. (2009). Long-term effects of neurofeedback treatment in autism. Research in Autism Spectrum Disorders, 3(2), pp.496-501.

ABSTRACT: Neurofeedback mediated suppression of theta power is supposed to promote more flexible functioning of the brain by enhancing activation in the medial prefrontal cortex and improving flexibility of activation in the default mode network supporting the improvement of executive functions and theory of mind in ASD.

15. Pineda, J., Brang, D., Hecht, E., Edwards, L., Carey, S., Bacon, M., Futagaki, C., Suk, D., Tom, J., Birnbaum, C. and Rork, A. (2008). Positive behavioral and electrophysiological changes following neurofeedback training in children with autism. Research in Autism Spectrum Disorders, 2(3), pp.557-581.

ABSTRACT: Two electrophysiological studies tested the hypothesis that operant conditioning of mu rhythms via neurofeedback training can renormalize mu suppression, an index of mirror neuron activity, and improve behavior in children diagnosed with autism spectrum disorders.

16. Ros, T., Moseley, M., Bloom, P., Benjamin, L., Parkinson, L. and Gruzelier, J. (2009). Optimizing microsurgical skills with EEG neurofeedback. BMC Neuroscience, 10(1), p.87.

ABSTRACT: By enabling individuals to self-regulate their brainwave activity in the field of optimal performance in healthy individuals, neurofeedback has been found to improve cognitive and artistic performance.

17. Lecomte, G. and Juhel, J. (2011). The Effects of Neurofeedback Training on Memory Performance in Elderly Subjects. Psychology, 02(08), pp.846-852.

ABSTRACT: Results showed that the members of the Neurofeedback group learned to increase the spectral power of the alpha frequency range as well as the alpha/thêta ratio, and that compared with the members of the two other groups, neurofeedback training resulted in a more pronounced decrease, albeit without any relation to changes in EEG activity and the level of stress and anxiety of participants undergoing such training

18. Becerra, J., Fernández, T., Harmony, T., Caballero, M., Garcia, F., Fernández-Bouzas, A., Santiago-Rodriguez, E. and Prado-Alcalá, R. (2006). Follow-Up Study of Learning-Disabled Children Treated with Neurofeedback or Placebo. Clinical EEG and Neuroscience, 37(3), pp.198-203.

ABSTRACT: This report is a 2-year follow-up to a previous study describing positive behavioral changes and a spurt of EEG maturation with theta/alpha neurofeedback (NFB) training in a group of Learning Disabled (LD) children. In a control paired group, treated with placebo, behavioral changes were not observed and the smaller maturational EEG changes observed were easily explained by increased age.

19. Ros, T., Théberge, J., Frewen, P., Kluetsch, R., Densmore, M., Calhoun, V. and Lanius, R. (2013). Mind over chatter: Plastic up-regulation of the fMRI salience network directly after EEG neurofeedback. NeuroImage, 65, pp.324-335.

ABSTRACT: Our findings provide neurobehavioral evidence for the brain’s exquisite functional plasticity, and for a temporally direct impact of NFB on a key cognitive control network, suggesting a promising basis for its use to treat cognitive disorders under physiological conditions.

20. Hanslmayr, S., Sauseng, P., Doppelmayr, M., Schabus, M. and Klimesch, W. (2005). Increasing Individual Upper Alpha Power by Neurofeedback Improves Cognitive Performance in Human Subjects. Applied Psychophysiology and Biofeedback, 30(1), pp.1-10.

ABSTRACT: Training success (extent of NFT-induced increase in upper alpha power) was positively correlated with the improvement in cognitive performance. Furthermore, the EEG of NFT responders showed a significant increase in reference upper alpha power.

21. Baehr, E., Rosenfeld, J. and Baehr, R. (1997). The Clinical Use of An Alpha Asymmetry Protocol in the Neurofeedback Treatment of Depression. Journal of Neurotherapy, 2(3), pp.10-23.

ABSTRACT: Using an Alpha Asymmetry protocol, the purpose of this training was to determine if depression could be alleviated when the subjects learned to increase the activation of the left hemisphere and/ or decrease the activation of the right hemisphere. The results suggest that Alpha Asymmetry neurofeedback training may be an effective adjunct to psychotherapy in the treatment of certain types of mood disorders.

22. Cheon, E., Koo, B. and Choi, J. (2015). The Efficacy of Neurofeedback in Patients with Major Depressive Disorder: An Open Labeled Prospective Study. Applied Psychophysiology and Biofeedback, 41(1), pp.103-110.

ABSTRACT: Neurofeedback treatment could improve depressive symptoms significantly. In addition, anxiety symptoms and clinical illness severity decreased significantly after neurofeedback treatment. Despite its several limitations, such as, small sample size and lack of a control group, this study suggested neurofeedback has significant effects in patients with major depressive disorder

23. Cantor, D. and Stevens, E. (2009). QEEG Correlates of Auditory-Visual Entrainment Treatment Efficacy of Refractory Depression. Journal of Neurotherapy, 13(2), pp.100-108.

ABSTRACT: The purpose of this study was to examine the use of auditory-visual EEG entrainment (AVE) at a 14 Hz (beta) frequency to decrease symptoms of depression with corresponding changes in neurophysiology. The findings indicate that AVE therapy may be a viable nonmedication therapeutic intervention.

24. Young, K., Siegle, G., Zotev, V., Phillips, R., Misaki, M., Yuan, H., Drevets, W. and Bodurka, J. (2017). Randomized Clinical Trial of Real-Time fMRI Amygdala Neurofeedback for Major Depressive Disorder: Effects on Symptoms and Autobiographical Memory Recall. American Journal of Psychiatry, 174(8), pp.748-755.

ABSTRACT: rtfMRI-nf training to increase the amygdala hemodynamic response to positive memories significantly decreased depressive symptoms and increased the percent of specific memories recalled on an autobiographical memory test. These data support a role of the amygdala in recovery from depression.

25. Hammond, D. (2000). Neurofeedback Treatment of Depression with the Roshi. Journal of Neurotherapy, 4(2), pp.45-56.

ABSTRACT: The very first Roshi session produced positive changes, and within five sessions the patient reported feeling less depressed and more energetic. At the conclusion of thirty training sessions, objective testing documented dramatic reductions in depression, somatic symptoms, over emotionality, anxiety, rumination, and fatigue. Obsessive-Compulsive Disorder

26. Hammond, D. (2003). QEEG-Guided Neurofeedback in the Treatment of Obsessive Compulsive Disorder. Journal of Neurotherapy, 7(2), pp.25-52.

ABSTRACT: An MMPI was ad- ministered pre-post to one patient, and she showed dramatic improve- ments not only in OCD symptoms, but also in depression, anxiety, somatic symptoms, and in becoming extroverted rather than introverted and withdrawn.

27. Barzegary, L., Yaghubi, H. and Rostami, R. (2011). The effect of QEEG- guided neurofeedback treatment in decreasing of OCD symptoms. Procedia – Social and Behavioral Sciences, 30, pp.2659-2662.

ABSTRACT: This research proves that neurofeedback training is an effective method for decreasing OCD symptoms. This research’s result is consistent to Hommnd’s studies (2003, 2004). Then, we can use neurefeedback for decreasing obsession and compulsion.

28. Sürmeli, T. and Ertem, A. (2011). Obsessive Compulsive Disorder and the Efficacy of qEEG-Guided Neurofeedback Treatment: A Case Series. Clinical EEG and Neuroscience, 42(3), pp.195-201.

ABSTRACT: According to follow-up interviews conducted with them and/or their family members 19 of the subjects maintained the improvements in their OCD symptoms. This study provides good evidence for the efficacy of NF treatment in OCD. The results of this study encourage further controlled research in this area.

29. Kunola, O. and Malley, O. (2007). EFFECTIVENESS OF NEUROFEEDBACK TRAINING IN CHRONIC INSOMNIA. 30th ed. [ebook] SLEEP 2007;30(Supplement):A265. Available at: https://neuroptimal.com/wp-content/uploads/2016/07/ZIN_okunola_insom_abstract_OMalley.pdf.

ABSTRACT: Early neurofeedback (EEG biofeedback) training protocols have been shown to be effective therapy for insomnia (Hauri et al 1982) and it is an integral component of CBT for insomnia.

30. Hoedlmoser, Pecherstorfer, Gruber, Anderer, Doppelmayr, Klimesch and Schabus (2008). Instrumental Conditioning of Human Sensorimotor Rhythm (12-15 Hz) and Its Impact on Sleep as Well as Declarative Learning. Sleep.

ABSTRACT: Relative SMR amplitude increased over 10 instrumental conditioning sessions (in the experimental group only) and this “shaping of one’s own brain activity” improved subsequent declarative learning and facilitated the expression of 12-15 Hz spindle oscillations during sleep. Most interestingly, these electrophysiological changes were accompanied by a shortened sleep onset latency.

31. Berner, I., Schabus, M., Wienerroither, T. and Klimesch, W. (2006). The Significance of Sigma Neurofeedback Training on Sleep Spindles and Aspects of Declarative Memory. Applied Psychophysiology and Biofeedback, 31(2), pp.97-114.

ABSTRACT: We conclude that the short NFT before sleep was not sufficient to efficiently enhance phasic spindle activity and/or to influence memory processing. NFT was, however, successful in increasing sigma power, presumably because sigma NFT effects become more easily evident in actually trained frequency bands than in associated phasic spindle activity

32. Kober, S., Schweiger, D., Witte, M., Reichert, J., Grieshofer, P., Neuper, C. and Wood, G. (2015). Specific effects of EEG based neurofeedback training on memory functions in post-stroke victims. Journal of NeuroEngineering and Rehabilitation, 12(1).

ABSTRACT: Post-stroke victims with memory deficits could benefit from NF training as much as healthy controls. The used NF training protocols (SMR, Upper Alpha) had specific as well as unspecific effects on memory. Hence, NF might offer an effective cognitive rehabilitation tool improving memory deficits of stroke survivors.

33. Reichert, J., Kober, S., Schweiger, D., Grieshofer, P., Neuper, C. and Wood, G. (2016). Shutting Down Sensorimotor Interferences after Stroke: A Proof-of-Principle SMR Neurofeedback Study. Frontiers in Human Neuroscience, 10.

ABSTRACT: Neurofeedback can be successfully applied in a stroke patient and in healthy elderly persons. We suggest that SMR neurofeedback leads to a shutting-down of sensorimotor interferences which benefits semantic encoding and retrieval.

34. Bearden TS, e. (2003). Neurofeedback training for a patient with thalamic and cortical infarctions. – PubMed – NCBI. [online] Ncbi.nlm.nih.gov. Available at: https://www.ncbi.nlm.nih.gov/pubmed/12964455.

ABSTRACT: Over the course of the training, significant reductions in theta amplitude occurred from the training sites as assessed from the post-session baseline periods. Posttraining, a relative normalization of the QEEG was observed from the left posterior head region.

35. Renton, T., Tibbles, A. and Topolovec-Vranic, J. (2015). Neurofeedback as a Form of Cognitive Rehabilitation Therapy Following Stroke: A Systematic Review. Archives of Physical Medicine and Rehabilitation, 96(12), p.e27.

ABSTRACT: Overall, modest positive improvements to a number of cognitive domains were identified following NFT initiation in a stroke population

36. Nelson, D. and Esty, M. (2012). Neurotherapy of Traumatic Brain Injury/Posttraumatic Stress Symptoms in OEF/OIF Veterans. The Journal of Neuropsychiatry and Clinical Neurosciences, 24(2), pp.237-240.

ABSTRACT: The Flexyx Neurotherapy System (FNS), a novel variant of EEG biofeedback, was adapted for intervention with seven treatment-refractory Afghanistan/Iraq war veterans, and brought about significant decreases in bothersome neurobehavioral and posttraumatic stress symptoms. FNS may help ameliorate mixed trauma spectrum syndromes.

38. Kim, S., Rath, J., Zemon, V., Cavallo, M., McCraty, R., Sostre, A. and Foley, F. (2018). Problem-solving, biofeedback, and severe brain injury: The moderating role of positive affect. Rehabilitation Psychology, 63(1), pp.148-154.

ABSTRACT: Participants who had the most positive emotions made the most gains in the HRV biofeedback training and performed better posttreatment on a test designed to measure problem-solving ability. Results indicate that positive affect can improve cognition, specifically mental flexibility and abstract thinking. Addressing factors that shape negative affect such as irrational beliefs and self-doubt is an important target for therapeutic intervention even in those with severe, chronic deficits.

39. Weiwei Peng, 2020,Individual variation in alpha neurofeedback training efficacy predicts pain modulation, Neuroimage Clin. 2020;28:102454. doi: 10.1016/j.nicl.2020.102454. Epub 2020 Sep 29.

ABSTRACT: NFB training decreased the sensory-discriminative aspect of pain, but increased the affective-motivational aspect of pain, whereas both pain modulations were dependent upon the NFB training efficacy. Importantly, correlation analysis across all participants revealed that a greater NFB training efficacy predicted a greater increase in pain thresholds particularly at hand contralateral to NFB target site.

40. Aleksandra Vučković, 2019, EEG Correlates of Self-Managed Neurofeedback Treatment of Central Neuropathic Pain in Chronic Spinal Cord Injury, Front Neurosci. 2019 Jul 25;13:762. doi: 10.3389/fnins.2019.00762. eCollection 2019.

ABSTRACT: Twelve participants achieved statistically significant reduction in pain and in eight participants this reduction was clinically significant (larger than 30%). The most successfully regulated frequency band during NFB was alpha. However, most participants upregulated their individual alpha band, that had an average dominant frequency at αp = 7.6 ± 0.8 Hz (median 8 Hz) that is lower than the average of the general population, which is around 10 Hz. Ten out of fifteen participants significantly upregulated their individual alpha power (αp ± 2 Hz) as compared to 4 participants who upregulated the power in the fixed alpha band (8-12 Hz). Eight out of the twelve participants who achieved a significant reduction of pain, significantly upregulated their individual alpha band power. There was a significantly larger increase in alpha power (p < 0.0001) and decrease of theta power (p < 0.04) in participant specific rather than in fixed frequency bands.

41. Alicja Kubik, 2013, Neurofeedback therapy in patients with acute and chronic pain syndromes–literature review and own experience, Przegl Lek. 2013;70(7):440-2

ABSTRACT: Pain management is based mainly on pharmacotherapy which has many limitations. Non-pharmacological techniques, like neurofeedback (EEG-biofeedback) are alternative methods of pain treatment. Data from literature confirm high efficacy of neurofeedback in pain syndromes treatment, chronic and acute as well. Neurofeedback plays an important role in management of post stroke, post traumatic headaches and in primary headaches like tension type headaches or migraine.

42. Kirsten Emmert, 2017, Active pain coping is associated with the response in real-time fMRI neurofeedback during pain, Brain Imaging Behav. 2017 Jun;11(3):712-721. doi: 10.1007/s11682-016-9547-0.

ABSTRACT: During neurofeedback, the pain coping was positively correlated with activation in the anterior cingulate cortex, prefrontal cortex, hippocampus and visual cortex. Thermode temperature was negatively correlated with anterior insula and dorsolateral prefrontal cortex activation. In conclusion, self-reported pain coping mechanisms and pain sensitivity are a source of variance during rt-fMRI neurofeedback possibly explaining variations in regulation success. In particular, active coping seems to be associated with successful pain regulation.

43. Mark P Jensen 1, Ann Gianas 1, Holly R George, 2016, Use of Neurofeedback to Enhance Response to Hypnotic Analgesia in Individuals With Multiple Sclerosis, Int J Clin Exp Hypn. 2016;64(1):1-23

ABSTRACT: This proof of principle study examined the potential benefits of EEG neurofeedback for increasing responsiveness to self-hypnosis training for chronic pain management. Participants were randomly assigned to have the prerecorded sessions preceded by either (a) EEG biofeedback (neurofeedback) training to increase left anterior theta power (NF-HYP) or (b) a relaxation control condition (RLX-HYP). Eighteen participants completed all treatment sessions and assessments. NF-HYP participants reported greater reductions in pain than RLX-HYP participants. The findings provide support for the potential treatment-enhancing effects of neurofeedback on hypnotic analgesia and also suggest that effective hypnosis treatment can be provided very efficiently.

44. Guangying Pei , Ruoshui Yang, 2020, Enhancing Working Memory Based on Mismatch Negativity Neurofeedback in Subjective Cognitive Decline Patients: A Preliminary Study, Front Aging Neurosci. 020 Sep 29;12:263. doi: 10.3389/fnagi.2020.00263. eCollection 2020.

ABSTRACT: Mismatch negativity (MMN) is suitable for studies of preattentive auditory discriminability and the auditory memory trace. Subjective cognitive decline (SCD) is an ideal target for early therapeutic intervention because SCD occurs at preclinical stages many years before the onset of Alzheimer’s disease (AD). Notably, after neurofeedback training, the working memory (WM) performance was significantly enhanced in the auditory tone 3-back test. Moreover, improvements in the accuracy of all WM tests relative to the baseline were observed. Our results suggest that MMN neurofeedback may represent an effective treatment for intervention in SCD patients and the elderly with aging memory decline.

45. Jung-Hee Jang, Jieun Kim, 2019, Beta wave enhancement neurofeedback improves cognitive functions in patients with mild cognitive impairment: A preliminary pilot study, Medicine (Baltimore). 2019 Dec;98(50):e18357.

ABSTRACT: Mild cognitive impairment (MCI) is a symptom characterizing cognitive decline and a transitional state between normal aging and dementia; however, there is no definitive diagnosis and treatment for MCI. Neurofeedback (NF), which is a training mechanism that employs operant conditioning to regulate brain activity, has been increasingly investigated concerning its beneficial effects for dementia and MCI. After completing the training, patients’ cognitive function significantly improved in domains such as composite memory, cognitive flexibility, complex attention, reaction time, and executive function. Increased electroencephalogram beta power was observed over NF training sessions. We suggest that patients’ cognitive processing efficiency was improved by the NF training. These beneficial results suggest that NF training may have potential therapeutic applications to prevent the progression from MCI to dementia.

46. Yotam Lavy, Tzvi Dwolatzky, 2021, Mild Cognitive Impairment and Neurofeedback: A Randomized Controlled Trial, Front Aging Neurosci. 2021 Jun 14;13:657646. doi: 10.3389/fnagi.2021.657646. eCollection 2021.

ABSTRACT: Mild cognitive impairment (MCI) is often a precursor of dementia, and in particular of Alzheimer’s Disease (AD) which is the most common cause of dementia. Individuals with amnestic MCI are several-fold more likely to develop AD than the general population. Therefore, MCI comprises a well-detectable, early stage time-point for therapeutic intervention and strategic prevention. Results: We witnessed a significant improvement in memory performance in subjects in the experimental group compared to those in the sham group. This improvement was maintained for at least 1 month. Conclusions: Neurofeedback may be a promising and affordable novel approach for treating the decline in memory witnessed in patients with MCI.

47. Kathrin C J Eschmann, Regine Bader, Axel Mecklinger, 2020, Improving episodic memory: Frontal-midline theta neurofeedback training increases source memory performance, Neuroimage. 2020 Nov 15;222:117219. doi: 10.1016/j.neuroimage.2020.117219. Epub 2020 Aug 1.

ABSTRACT: Cognitive and neurofeedback training (NFT) studies have demonstrated that training-induced alterations of frontal-midline (FM) theta activity (4-8 Hz) transfer to cognitive control processes. Given that FM theta oscillations are assumed to provide top-down control for episodic memory retrieval, especially for source retrieval, that is, accurate recollection of contextual details of prior episodes, the present study investigated whether FM theta NFT transfers to memory control processes. Over seven NFT sessions, the training group who trained individual FM theta activity showed greater FM theta increase than an active control group who trained randomly chosen frequency bands. The training group showed better source retrieval in a posttraining session performed 13 days after NFT and their performance increases from pre- to both posttraining sessions were predicted by NFT theta increases. EEG analyses revealed that during pretest both groups showed source memory specific theta activity at frontal and parietal sites. Surprisingly, training-induced improvements in source retrieval tended to be accompanied by less prestimulus FM theta activity, which was predicted by NFT theta change for the training but not the control group, suggesting a more efficient use of memory control processes after training. The present findings provide unique evidence for the enhancement of memory control processes by FM theta NFT.

48. Mohammad Nazer, Hanifeh Mirzaei, 2018, Effectiveness of neurofeedback training on verbal memory, visual memory and self-efficacy in students, Electron Physician. 2018 Sep 9;10(9):7259-7265. doi: 10.19082/7259. eCollection 2018 Sep.

ABSTRACT: Background: Memory is the basis for the development of language skills and learning processes, and self-efficacy is one of the most important predictors of academic achievement.

Objective: This study aimed to determine the effects of neurofeedback training (NFB) on verbal and visual memory and self-efficacy in students of Rafsanjan University of Medical Sciences.

Results: The Mean±SD of verbal memory in the experimental group in pretest, posttest and follow-up was 20±1.9, 22.58±2.1, 22.41±2.06 respectively (p 0.001, Effect size= 0.53).There were significant changes in short-term (p=0.001, Effect size =0.41) and long-term (p=0.001, Effect size =0.42) visual memory.

Conclusion: NFB is effective in improving verbal memory and some dimensions of visual memory.

49. Limor Shtoots, Tom Dagan, Josh Levine, Aryeh Rothstein, Liran Shati, Daniel A Levy, The Effects of Theta EEG Neurofeedback on the Consolidation of Spatial Memory, Clin EEG Neurosci. 2021 Sep;52(5):338-344. doi: 10.1177/1550059420973107. Epub 2020 Nov 18.

ABSTRACT: How can the stability of a recently acquired memory be improved? Recent findings regarding the importance of theta frequency EEG activity in the hippocampus suggest that entraining neural activity in that frequency band might increase post-encoding waking replay, reinforcing learning-related plasticity. Our previous studies revealed that upregulating postlearning theta power using EEG neurofeedback (NFB) significantly benefitted procedural and episodic memory performance (both immediate and delayed), and may provide optimal conditions for stabilization of new memories. We have now explored whether memory benefits of theta NFB generalize to delayed spatial memory, an additional hippocampus-dependent process. Theta upregulation was found to improve visuo-spatial memory, as reflected in reduced error distances in location marking and faster reaction time for correct answers by the theta group. This supports the contention that theta upregulation immediately after learning strengthens early consolidation of visuo-spatial memory. This intervention could potentially benefit various memory-challenged populations, as well as healthy individuals.

50. Tanju Sürmeli, Ayben Ertem, 2011, Obsessive compulsive disorder and the efficacy of qEEG-guided neurofeedback treatment: a case series. Clin EEG Neurosci. 2011 Jul;42(3):195-201. doi: 10.1177/155005941104200310.

ABSTRACT: Thirty-six drug resistant subjects with OCD were assigned to 9-84 sessions of QEEG-guided NF treatment. Daily sessions lasted 60 minutes where 2 sessions with half-hour applications with a 30 minute rest given between sessions were conducted per day. Thirty-three out of 36 subjects who received NF training showed clinical improvement according to the Yale-Brown obsessive-compulsive scale (Y-BOCS). The Minnesota multiphasic inventory (MMPI) was administered before and after treatment to 17 of the subjects. The MMPI results showed significant improvements not only in OCD measures, but all of the MMPI scores showed a general decrease. Finally, according to the physicians’ evaluation of the subjects using the clinical global impression scale (CGI), 33 of the 36 subjects were rated as improved. Thirty-six of the subjects were followed for an average of 26 months after completing the study. According to follow-up interviews conducted with them and/or their family members 19 of the subjects maintained the improvements in their OCD symptoms. This study provides good evidence for the efficacy of NF treatment in OCD. The results of this study encourage further controlled research in this area.

51. D Corydon Hammond. 2005, Neurofeedback with anxiety and affective disorders, Child Adolesc Psychiatr Clin N Am. 2005 Jan;14(1):105-23, vii. doi: 10.1016/j.chc.2004.07.008.

ABSTRACT: A robust body of neurophysiologic research is reviewed on functional brain abnormalities associated with depression, anxiety, and obsessive-compulsive disorder. A review of more recent research finds that pharmacologic treatment may not be as effective as previously believed. A more recent neuroscience technology, electroencephalographic (EEG) biofeedback (neurofeedback), seems to hold promise as a methodology for retraining abnormal brain wave patterns. It has been associated with minimal side effects and is less invasive than other methods for addressing biologic brain disorders.

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